GLP-1 Weight management medications

GLP-1 weight loss

Which GLP-1 works best for weight loss?

Weight loss can be challenging for many individuals, even when they maintain a well-balanced diet and exercise plan. As a result, some individuals may search for additional weight-loss strategies, such as weight-loss medication.

The Food and Drug Administration (FDA) recently approved semaglutide, also marketed under the name Wegovy, as a common drug. This drug is intended to lessen hunger and calorie consumption, possibly assisting in weight loss. There are numerous other GLP-1 weight loss medications available, and many of them are frequently recommended for weight loss off-label.

The Food and Drug Administration (FDA) has currently approved the new drug treatment for a number of GLP-1 agonists for the treatment of severe obesity. These include liraglutide (Saxenda), semaglutide (Wegovy), and exenatide (Byetta). While all three drugs work by mimicking the effects in the body.

In order to support weight management, doctors frequently prescribe these weight loss medications along with other drug interactions and weight reduction strategies, including a reduced-calorie diet and an exercise program.

Does GLP-1 help you lose weight?

Both liraglutide and semaglutide have been shown to be effective for weight loss in clinical trials. In a randomized, double-blind study, liraglutide was found to be more effective than a placebo group for weight loss in obese adults with type 2 diabetes.

Semaglutide has also been found to be effective for weight loss in clinical trials. In fact, a recent study found that semaglutide was more effective than liraglutide for losing weight in obese adults, even under a different placebo group.

In fact, numerous studies have demonstrated that GLP-1 receptor agonists can aid in weight reduction. For instance, a study found that obese patients who took the semaglutide for 68 weeks on average weight loss dropped 15% of their body weight.

The report was published in the New England Journal of Medicine. According to a different study that was published in Diabetes Care, individuals with type 2 diabetes who took liraglutide for 56 weeks, on average, lost 5.9% of their body weight.

Do you need a prescription for GLP-1?

Prescription drugs known as GLP-1 (glucagon-like peptide-1) receptor agonists are generally used to treat type 2 diabetes. They have, however, also been approved for use in helping certain individuals to decrease their weight. Due to their prescription status, you must visit a doctor and get a prescription before using these medications.

These medications come in various forms, including name-brand medicines like Ozempic, Trulicity, and Victoza. Depending on the substance, these medications are often given by injection, either once a week or once a day.

If you’re interested in taking the drug, you will need a prescription from a healthcare professional. These medications are not available over the counter and can only be obtained through a prescription.

You must discuss your medical history, current medications, and any additional health problems with your doctor in order to get a prescription. Your healthcare professional can assess if the drug is right for you and can supply you with a prescription if appropriate.

If it is deemed appropriate, the professional will provide a prescription. Insurance coverage may be available for these medications, which can help make them more affordable.

Can non-diabetics take GLP?

While type 2 diabetes and obesity are the main conditions that GLP-1 agonists are used to treat, there is some evidence to suggest that they may also have additional health advantages aside from meaningful weight loss and metabolic health.

For example, some studies have suggested that GLP-1 receptor agonists may assist in lowering high blood pressure, improving cholesterol levels, and reducing inflammation.

However, it’s crucial to remember that GLP-1 receptor agonists are not licensed for usage in non-diabetics, and there is limited information on their safety and effectiveness in this population.

However, because non-diabetics don’t have the same problems with blood sugar regulation as diabetics do, these medications can have side effects, including nausea, vomiting, and diarrhea that can be more severe.

While there is some evidence to suggest that GLP-1 agonists may have health benefits beyond their approved use for type 2 diabetes and obesity, non-diabetics should not take these medications without a prescription and guidance from a healthcare professional.

Is GLP-1 the same as Ozempic?

A hormone called GLP-1 (glucagon-like peptide-1) is crucial for controlling appetite and blood glucose levels. Drugs that act as GLP-1 agonists, like Ozempic (semaglutide), mimic the effects of this hormone and can lower blood glucose and aid in weight loss.

While Ozempic can come in different forms, there are other similar drugs available as well, such as Victoza (liraglutide) and Byetta (exenatide). Similar to Ozempic in their mode of action, these drugs may have slightly different dosing or administration guidelines.

It’s critical to remember that these types of drugs should only be used when guided by a healthcare professional.

How can I increase my GLP-1 naturally?

While type 2 diabetes and obesity can be effective for patients treated with GLP-1 agonist medications, some individuals may be interested in raising their GLP-1 levels naturally. These are some methods to raise these levels naturally.

Eat a fiber-rich diet

Fruits, vegetables, and whole grains are examples of foods high in fiber that can help raise GLP-1 levels. This is because fiber takes longer to digest than sugar, which can delay the release of GLP-1.

Add more protein to your diet

Adding additional protein to your diet may help you naturally raise your GLP-1 levels because protein has been demonstrated to boost the release of GLP-1. Meat, fish, eggs, and beans are examples of protein sources.

Work out regularly

Type 2 diabetes and healthy individuals have higher GLP-1 levels after exercise. Try to exercise for at least 30 minutes, most days of the week, for chronic weight management at a moderate level.

Getting enough sleep

It’s crucial to obtain adequate sleep every night because it has been shown that getting less sleep will lower GLP-1 levels. Adults typically require 7-9 hours of sleep per night.

Manage your stress levels

Finding ways to manage stress is important because prolonged stress can result in lower GLP-1 levels. This might entail engaging in relaxation exercises for chronic weight management like yoga or deep breathing.

While it’s crucial to keep in mind that these natural approaches might not be sufficient for everyone, they may help to raise GLP-1 levels.

Which GLP-1 agonist is best for weight loss?

GLP-1 (glucagon-like peptide-1) agonist medications, such as Ozempic (semaglutide), Victoza (liraglutide), and Byetta (exenatide), have been shown to be effective for weight loss in addition to their primary use for treating type 2 diabetes. However, which GLP-1 agonist is best for weight loss can depend on individual factors and preferences.

Semaglutide, the active ingredient in Ozempic, has been shown to be highly effective for weight loss. An injection of semaglutide is given once per week.

The active component in Victoza, liraglutide, has also demonstrated efficacy for weight loss. Daily injections of liraglutide are used to provide it.

Exenatide, the active ingredient in Byetta, has also been shown to be effective for weight loss. Injections of exenatide are given twice daily. Liraglutide (Victoza), exenatide (Byetta), and semaglutide (Ozempic) have all been demonstrated to be highly successful for weight loss.

It’s important to remember that these medications may not be suitable for everyone and can cause side effects like nausea, vomiting, and diarrhea.

Working with a healthcare professional will help you choose the drug that will be most effective for you, given your medical history, existing medications, and other health issues.

Which GLP-1 drugs are approved for weight loss?

In addition to their primary purpose of treating type 2 diabetes, GLP-1 (glucagon-like peptide-1) agonist drugs are also licensed for use in the treatment of obesity. The Food and Drug Administration (FDA) approved the following GLP-1 agonist drugs for weight loss:

A continued weekly subcutaneous semaglutide (Ozempic) injection has been proven to be quite helpful for weight loss. Later, it was approved for use in individuals with a body mass index (BMI) of 27 or above weight gain and those with at least one weight-related health problem, such as high blood pressure or type 2 diabetes, to promote weight loss.

Liraglutide (Saxenda), which is administered as a daily injection, has also been proven to help individuals decrease weight without any weight regain. Another injectable drug with its roots in treating type 2 diabetes is Saxenda.

It was subsequently approved for use in individuals with a BMI of 30 or higher or those with a BMI of 27 or higher who also have at least one weight-related health problem to promote weight loss.

In June 2021, the FDA approved the once weekly semaglutide injection of dulaglutide (Trulicity) for treating obesity.

Wegovy (semaglutide) was only recently approved by the FDA for weight management in individuals with obesity or overweight, weight gain, and at least one weight-related health condition. Wegovy contains a larger dose of semaglutide than Ozempic.

The FDA approved the use of semaglutide, liraglutide, and dulaglutide for weight loss. Talking with a healthcare professional will help you choose the drug that will work the best for you, given your unique needs and preferences.

Despite the fact that these drugs may help individuals decrease weight regain, they are not an antidote. They are often used as a component of a whole weight management strategy involving dietary adjustments, physical activity, and other healthy lifestyle adjustments.

Working with a healthcare professional will help you choose the drug that will be most effective for you, given your medical history, existing medications, and other health issues.

Weight management

How fast do you lose weight on GLP-1?

It has been demonstrated that GLP-1 (called glucagon-like peptide-1) agonists are effective treatments for weight loss within a relatively short period of time in trials. These drugs control blood glucose levels and suppress hunger, which lowers food intake and promotes weight loss. But how quickly can you anticipate seeing the effects of using GLP-1 agonists to decrease weight?

Depending on the individual and the particular prescription they are taking, the answer to this question may differ. GLP-1 agonists, on the other hand, have been demonstrated in further trials to cause significant weight loss in a relatively short amount of time.

Participants who took semaglutide (Ozempic) over the course of 68 weeks in a clinical trial lost an average of 15% of their body weight. Nonetheless, weight loss that was noticeable started as early as week 16 of the clinical trial. In a different liraglutide (Saxenda) clinical trial, individuals who took the drug lost an average of 5.9% of their body weight over the course of 56 weeks, with a significant weight loss seen as early as week 12.

It’s important to remember that weight reduction varies from person to person and may be influenced by elements including nutrition, activity, and general health. It’s crucial to collaborate with a healthcare professional or weight management specialist to create a specialized treatment plan if you’re considering using GLP-1 agonists to decrease weight. To achieve the best outcomes, this may involve a combination of medicine, diet, exercise, and other lifestyle changes.

How does GLP-1 decrease weight?

The body naturally produces the hormone GLP-1 (glucagon-like peptide-1) to control blood glucose levels and promote insulin secretion. These drugs imitate this hormone’s properties and have been proven successful in helping individuals decrease weight. When GLP-1 agonists are used for weight loss, they help to reduce food intake by decreasing hunger and increasing feelings of fullness.

So how exactly can GLP-1 reduce weight? Well, many mechanisms are active. First, it has been demonstrated that GLP-1 agonists decrease hunger by delaying gastric emptying and enhancing sensations of fullness. As a result, fewer calories are consumed, which may help with weight loss.

A group of drugs known as GLP-1 agonists imitate the effects of the GLP-1 hormone, which the body produces naturally. In reaction to eating, the intestines secrete GLP-1, which lowers hunger, enables gastric emptying, increases fullness, and helps to control blood glucose levels.

The drug can aid in the reduction of oxidative stress and inflammation in the body, both of which have been linked to obesity and other chronic diseases or disorders. Last, but not least, it has been demonstrated that such drugs can raise energy expenditure, or the number of calories the body burns while at rest. This could support weight loss efforts even more.

Finally, drug treatment can also help to reduce the amount of fat stored in the body. This is because they can activate specific receptors in fat cells, causing them to break down and release stored fat for energy. This can lead to a reduction in overall body fat, which can contribute to weight loss.

How long does it take to lose weight on GLP-1?

You might wonder how long it takes to see benefits if you’re considering using GLP-1 agonists to aid in weight loss. The answer to this question can vary depending on several factors, including your starting weight, your diet and exercise habits, and the specific GLP-1 agonist you are using.

Studies have generally shown that individuals using GLP-1 agonists can anticipate losing 5–10% of their body weight on average weight loss over the course of 6–12 months. Individual outcomes can differ, and based on their unique situations, some individuals may lose more or less weight.

It’s important to remember that weight loss on GLP-1 agonists usually happens gradually rather than quickly. Within the first few weeks of taking the drug, you might start to notice some changes in your weight, but it might take several months to lose a considerable amount of weight.

To maximize the effects of GLP-1 agonists, it’s crucial to maintain a good diet and exercise routine in addition to taking the drug. This can involve regular weight loss maintenance, a regular physical exercise schedule, such as walking, running, or strength training, as well as consuming a balanced diet that is high in fruits, vegetables, lean meats, and whole grains.

Who should not take GLP-1?

GLP-1 agonists can be an effective treatment option for individuals who are struggling with obesity and have a personal or family history of related health conditions. Nonetheless, there are special cases in which using GLP-1 agonists would not be advised or safe.

Those with a history of pancreatitis or pancreatic cancer are among those individuals who shouldn’t use GLP-1 agonists. This is because GLP-1 agonists may raise the likelihood that certain illnesses will manifest or may worsen current problems.

GLP-1 agonists should also be avoided by those with a history of thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN 2), as these conditions may increase the risk of medullary thyroid carcinoma.

Furthermore, GLP-1 agonists should not be advised for individuals with serious gastrointestinal conditions like gastroparesis. Women who are pregnant or nursing should also stay away from GLP-1 agonists because it is unclear how they will affect the growth of the fetus or the supply of breast milk.

Before beginning therapy with GLP-1 agonists, it’s crucial to discuss any additional medications you’re taking with your healthcare provider because some medications and GLP-1 agonists may interfere.

What are the examples of GLP-1 drugs?

Drugs of the GLP-1 (glucagon-like peptide-1) class imitate the effects of the GLP-1 hormone in the body. After meals, this hormone is released in the gut and aids in controlling blood sugar levels by encouraging the pancreas to release insulin.

GLP-1 medications trigger the body’s GLP-1 receptor, which increases insulin production, decreases glucagon release (another hormone that elevates blood sugar), slows gastric emptying (the pace at which food leaves the stomach), and intensifies sensations of fullness.

These are a few examples of GLP-1 medications:

Ozempic (semaglitude)

Type 2 diabetes and obesity can be treated with this once-weekly injection. It functions by suppressing hunger and slowing down food digestion, which may result in weight loss due to lower food intake.

Victoza (liraglitude)

A once-daily injectable that has been licensed to treat type 2 diabetes may also be used off-label to help individuals decrease their weight. It functions similarly to other GLP-1 medications by decreasing hunger and delaying digestion.

Adlyxin (lixisenatide)

This medication for type 2 diabetes is administered via daily injection. It suppresses appetite and slows down the digestion of food.

Trulicity (dulaglutide)

This once-weekly injection is approved for treating type 2 diabetes and obesity. It suppresses appetite and slows down the digestion of food.

It is important to remember that not all GLP-1 medications are expressly licensed for weight loss and that the doses used for weight loss may vary from those used for managing diabetes.

These drugs need a doctor’s prescription to be used, and they should only be done under supervision. They might not be suitable for everyone, and it’s important to consider any potential adverse effects or combinations with other medications.

Consult your doctor to assess the best course of treatment for your specific needs if you’re considering utilizing GLP-1 medications for weight loss or diabetes management.

Lose weight!

Who can take GLP-1 for weight loss?

Some individuals may utilize GLP-1 (glucagon-like peptide-1) drugs, sometimes called GLP-1 receptor agonists, to help them decrease weight. Not everyone, however, qualifies as a good candidate for this kind of treatment.

GLP-1 medications are frequently approved for usage in individuals with type 2 diabetes who struggle with obesity. They function by decreasing hunger, slowing down meal digestion, and assisting in controlling blood glucose levels. They may, therefore, successfully encourage beneficial weight management in these individuals.

GLP-1 medications can be taken off-label by individuals without diabetes to decrease weight. Not everyone, however, qualifies as a good candidate for this kind of treatment. Those with a history of thyroid cancer or pancreatitis may not want to take GLP-1 medications.  Lastly, they may also not be suitable for individuals with severe kidney or liver disease.

If you’re thinking about taking GLP-1 drugs to decrease weight, consult your doctor to see if this course of treatment is appropriate for you.

How Does GLP-1 work for weight loss?

Drugs that target the GLP-1 (glucagon-like peptide-1) receptor, sometimes referred to as GLP-1 receptor agonists, have long been authorized for the treatment of type 2 diabetes. Recent research has demonstrated that they can also be useful for weight loss in some individuals.

GLP-1 medications function by focusing on the body’s GLP-1 receptor agonist. The surface of some cells in the pancreas, gut, and brain contain this receptor. The receptor can cause various physiological reactions that can aid in promoting weight reduction when GLP-1 receptor agonist medications trigger it.

By delaying the digestion of meals, GLP-1 receptor agonists help individuals decrease weight in one of its main methods. Some individuals may feel less hungry and more satisfied for longer periods of time as a result. Moreover, GLP-1 drugs can assist in controlling individuals who take glycerine control measures to obtain low blood sugar levels, which can further support appetite suppression and weight loss.

GLP-1 receptor drugs also have other health benefits on the body that can aid in weight loss. For instance, they can boost insulin production, which aids in controlling blood glucose levels and preventing the storage of extra glucose as fat. They can also lessen the glucagon hormone’s output, stimulating the liver to create glucose.

Overall, GLP-1 receptor drugs can help some individuals decrease their weight by enhancing feelings of satiety, controlling blood sugar levels, and boosting insulin production.


Dr. Gabriela Rodriguez specializes in General and Laparoscopic Bariatric Surgery. She brings to VIDA Wellness and Beauty a wealth of experience in bariatrics. Dr. Rodriguez is a founding associate of the Mexican College of General Surgeons. A world-class bariatric surgeon with double certification in the US and Mexico.